Cajun Chicken and Shrimp Alfredo is a tasty mix of bold spices and creamy comfort. You get juicy chicken and shrimp with that perfect kick from Cajun seasoning, all tossed in a rich, creamy Alfredo sauce that hugs every bite of pasta. It’s a meal that feels fancy but is really easy to make, with just the right balance of spice and creaminess.
I love making this dish when I want something a little special but still homey. The Cajun seasoning adds a nice smoky heat that wakes up the tender chicken and shrimp. One thing I like to do is give the shrimp just a quick sear so it stays juicy and bright. It’s a great way to enjoy a restaurant-style dinner without the fuss.
My favorite way to serve this is with some fresh parsley sprinkled on top and warm garlic bread on the side. It’s a crowd-pleaser and always gets compliments when I bring it to a dinner. Plus, it’s perfect for leftovers, which I’m always happy about. If you like creamy pasta with a bit of spice, this dish will likely become one of your go-tos too.
Key Ingredients & Substitutions
Cajun seasoning: This adds the dish’s bold, spicy flavor. If you don’t have Cajun seasoning, you can mix paprika, garlic powder, onion powder, cayenne pepper, and dried herbs for a similar taste.
Chicken breast: Using bite-sized pieces helps them cook quickly and evenly. You can swap for chicken thighs if you want juicier meat, but adjust cooking time slightly.
Shrimp: Fresh or frozen shrimp both work well. Just make sure to thaw frozen shrimp completely and dry them before cooking to get a nice sear.
Heavy cream and milk: The combo makes a smooth, creamy sauce without being too heavy. For a lighter version, try half-and-half or a milk substitute, but the sauce may be less rich.
Parmesan cheese: It melts beautifully and adds sharp, nutty flavor. If needed, Romano or Asiago cheese can substitute in a pinch.
How Do I Cook the Chicken and Shrimp Without Overcooking?
Getting tender chicken and juicy shrimp is key. Here’s how I handle it:
- Season both with Cajun seasoning for flavor and a bit of crust.
- Cook the chicken first over medium-high heat until browned and cooked through, about 5-7 minutes. Don’t crowd the pan to avoid steaming.
- Remove the chicken and use the same pan for the shrimp, cooking for about 2-3 minutes per side until pink and just opaque. Shrimp cook fast, so watch closely!
- Rest the cooked proteins while you make the sauce, then add them back to warm through without extra cooking.
Equipment You’ll Need
- Large skillet – perfect for cooking chicken, shrimp, and making the sauce all in one pan.
- Pot for boiling pasta – you want something big enough to cook pasta evenly without sticking.
- Tongs or pasta fork – makes tossing pasta with sauce easier and less messy.
- Measuring cups and spoons – for accurate seasoning and sauce ingredients.
- Grater – to freshly grate Parmesan cheese for the best flavor and smooth melting.
Flavor Variations & Add-Ins
- Swap chicken for sausage slices for a smokier, spicier twist that pairs well with Cajun flavors.
- Add sautéed bell peppers and onions for a sweet crunch and extra veggies.
- Use smoked paprika or chipotle powder in place of Cajun seasoning for a deeper smoky heat.
- Stir in sun-dried tomatoes or fresh spinach at the end for extra color and mild flavor boost.
How to Make Cajun Chicken and Shrimp Alfredo
Ingredients You’ll Need:
Main Ingredients:
- 8 oz fettuccine or linguine pasta
- 1 lb chicken breast, cut into bite-sized pieces
- ½ lb large shrimp, peeled and deveined
- 2 tablespoons Cajun seasoning, divided
- 2 tablespoons olive oil, divided
- 4 tablespoons unsalted butter
- 4 cloves garlic, minced
- 1 cup heavy cream
- 1 cup whole milk
- 1 cup freshly grated Parmesan cheese
- Salt and black pepper to taste
- Fresh parsley, chopped (for garnish)
Time You’ll Need:
This recipe takes about 30 minutes total, including preparation and cooking. Cooking pasta and sautéing the chicken and shrimp are quick steps, and the creamy sauce comes together fast. It’s perfect for a tasty weeknight meal!
Step-by-Step Instructions:
1. Cook the Pasta:
Bring a large pot of salted water to a boil and cook the pasta according to the package instructions until al dente. Drain the pasta, reserving about half a cup of pasta water, and set the pasta aside.
2. Cook the Chicken:
Season the chicken pieces with 1 tablespoon of Cajun seasoning. Heat 1 tablespoon of olive oil in a large skillet over medium-high heat. Add the chicken and cook until nicely browned and cooked through, about 5 to 7 minutes. Remove the chicken from the skillet and set it aside.
3. Cook the Shrimp:
Season the shrimp with the remaining 1 tablespoon of Cajun seasoning. In the same skillet, add the remaining 1 tablespoon olive oil. Sear the shrimp for 2 to 3 minutes per side until they turn pink and are opaque. Remove the shrimp from the skillet and set aside.
4. Make the Alfredo Sauce:
Reduce heat to medium and melt the butter in the skillet. Sauté the minced garlic for about 1 minute until fragrant. Slowly add heavy cream and milk, stirring to combine. Let the sauce simmer gently for 3 to 4 minutes until it starts to thicken. Stir in the freshly grated Parmesan cheese until the sauce is smooth. Season with salt and black pepper to taste.
5. Combine Everything:
Add the cooked pasta to the skillet, tossing it well in the creamy sauce. If the sauce feels too thick, add the reserved pasta water one tablespoon at a time until it reaches the consistency you like. Return the chicken and shrimp to the pan and gently stir to combine and warm through.
6. Serve and Enjoy:
Sprinkle the dish with fresh chopped parsley and, if you like, additional Parmesan cheese. Serve immediately and enjoy your creamy, spicy Cajun Chicken and Shrimp Alfredo!
Can I Use Frozen Shrimp for This Recipe?
Yes, frozen shrimp works great! Just make sure to fully thaw and pat them dry before cooking to avoid excess moisture, which can prevent a good sear.
How Can I Make This Dish Spicier or Milder?
To spice it up, add extra Cajun seasoning or a pinch of cayenne pepper. For a milder version, reduce the Cajun seasoning by half and balance with a little extra garlic or herbs.
What’s the Best Way to Store Leftovers?
Store leftovers in an airtight container in the fridge for up to 3 days. Reheat gently on the stove or in the microwave, stirring occasionally to keep the sauce smooth.
Can I Prepare This Dish Ahead of Time?
You can cook the chicken, shrimp, and pasta in advance and refrigerate separately for up to 2 days. Reheat them together in the sauce just before serving for the best flavor and texture.
